A new study suggests a ‘significant’ link between androgen deficiency and breast cancer risk
RTE link article A new US study has shown that those with a low level of androgen, as in those who have a family history of breast cancer, are at increased risk of developing breast cancer.
The research, led by a research team from the University of Minnesota, looked at a group of 6,000 women aged 40 to 55 who had breast cancer in Minnesota.
The women were randomly assigned to either receive a hormone therapy, which blocks androgen receptors from attaching to androgen to create the hormone progesterone, or receive an anti-androgen treatment.
Researchers found that the hormone therapy group was 20 per cent more likely to develop breast cancer compared with the anti- androgen group.
They also found that women who had the hormone treatment group were about 25 per cent less likely to die from breast cancer than women in the anti androgen treatment group.
We have known for some time that there is a correlation between high levels and higher rates of cancer. “
We know that high levels ofandrogen, especially in the prostate, are linked to prostate cancer.”
We have known for some time that there is a correlation between high levels and higher rates of cancer.
We wanted to know whether the same is true for androgen levels.
“Dr Mary Jo Brown, of Northwestern University’s Institute for Gender Research, said the findings were important for women who wanted to reduce their risk of cancer by increasing their levels of progesterones.
She said:”The progesteronoid hormone receptor is a receptor for a protein that is important in regulating cell growth.”
When it is inhibited by an anti androstenedione treatment, the cell will start to shrink, and this is bad for the patient’s health.”
It also reduces cell growth, so it is important to prevent or at least slow the rate at which cells grow in these cells, which will help protect them from further damage.
“If we can reduce the level of progestogen in the blood, that will reduce the risk for breast cancer.”
Dr Brown added that the study’s findings had also been replicated in other large US studies, which had shown that men who had low levels, androgen deficiencies, were more likely than men with normal levels to develop prostate cancer, even after adjusting for factors such as age, income and smoking.
She added: “If we are to reduce the breast cancer incidence, it is very important to reduce both androgen and androgen-related factors.”
Professor McNeill said the results of this new study were promising.
“There are some interesting things that we can learn from it.”
The anti-inflammatory agents androgenic agents may be the most important of all, and we may also see that these drugs reduce breast cancer progression.
“This is very promising.”
Read more:New research finds ‘significant risk’ for breast cancers in women with low levels